Recent evidence has shown that alternatively spliced genes occur quite frequently in the human genome. Various studies put the percentage of genes with alternatively spliced transcripts at around %20 to %60. Furthermore, it is estimated that alternative splicing (AS) is commonly involved in human disease. An understanding of the regulatory mechanisms of AS is, therefore, crucial, as is the annotation of AS in genomic data.
In 2006 we will begin a quantitative genetic investigation of the regulatory control of AS in the mouse genome. We will investigate the relationship of genome sequence variation and the expression of different isoforms. Our aim is to identify cis-acting splicing regulatory motifs and trans-acting splicing factors.
More to come...
